EXPRESSION OF RETINOIC ACID RECEPTOR GENES IN NEURAL CREST-DERIVED CELLS DURING MOUSE FACIAL DEVELOPMENT

被引：78

作者：

OSUMIYAMASHITA, N

NOJI, S

NOHNO, T

KOYAMA, E

DOI, H

ETO, K

TANIGUCHI, S

机构：

[1] OKAYAMA UNIV, SCH DENT,DEPT BIOCHEM,2-5-1 SHIKATA CHO, OKAYAMA 700, JAPAN

[2] FUJITSU LTD, IIAS SIS,OHOTA KU, TOKYO 144, JAPAN

[3] KAWASAKI MED SCH, DEPT PHARMACOL, KURASHIKI, OKAYAMA 70101, JAPAN

[4] TOKYO MED & DENT UNIV, FAC DENT,BUNKYO KU, TOKYO 113, JAPAN

来源：

FEBS LETTERS | 1990年 / 264卷 / 01期

关键词：

D O I：

10.1016/0014-5793(90)80767-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Retinoic acid (RA) is known as a teratogen that induces abnormalities in facial structures which are made up mainly of neural crest-derived mesenchyme. We investigated expression patterns of RA receptor (RAR) genes (subtypes α, β, γ) during mouse facial development. The expression of the rarβ gene is specific for the mesenchyme around developing eyes and nose, whereas the RARγ gene is expressed in the mesenchyme differentiating to facial cartilages and bones. In contrast, the RARα gene is expressed weakly and uniformly over the facial region. These results suggest that crucial roles of endogenous RA in facial development depend on differential functions of the RAR subtypes. © 1990.

引用

页码：71 / 74

页数：4

共 17 条

[1] DIFFERENTIAL EXPRESSION OF GENES ENCODING ALPHA,BETA AND GAMMA-RETINOIC ACID RECEPTORS AND CRABP IN THE DEVELOPING LIMBS OF THE MOUSE [J].