SAMPLE-SIZE DETERMINATION FOR CASE-CONTROL STUDIES - THE INFLUENCE OF THE JOINT DISTRIBUTION OF EXPOSURE AND CONFOUNDER

被引：5

作者：

LUI, KJ

机构：

[1] Department of Mathematical Sciences, College of Sciences, San Diego State University, San Diego, California

来源：

STATISTICS IN MEDICINE | 1990年 / 9卷 / 12期

关键词：

D O I：

10.1002/sim.4780091212

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In case‐control studies, the results about how the exposure distribution affects sample size are well known. This paper extends previous results by incorporating the effect of a confounder into the calculation of sample size for a desired size and power of a statistical test. The paper also includes a quantitative discussion on the influence of the joint distribution for exposure to a putative cause and a confounder on required sample sizes. The results show that, to detect a specified alternative for a given size and power, the required sample size decreases as either the variance of exposure or the effect of exposure on disease increases. The required sample size, however, increases as either the variance of the confounder or the effect of the confounder on disease increases. Generally, the higher is the absolute value of the simple correlation between the exposure and the confounder, the larger is the required sample size. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：1485 / 1493

页数：9

共 17 条

[1]

Fleiss J.L., Statistical Methods for Rates and Proportions, (1973)

[2]

Lui K.-J., Estimation of sample sizes in case‐control studies with multiple controls per case: dicho‐tomous data, American Journal of Epidemiology, 127, pp. 1064-1070, (1988)

[3]

Schlesselman J.J., Case‐Control Studies, (1982)

[4]

Schlesselman J.J., Sample size requirements in cohort and case‐control studies of disease, American Journal of Epidemiology, 99, pp. 381-384, (1974)

[5]

Feigl P.A., A graphical aid for determining sample size when comparing two independent proportions, Biometrics, 34, pp. 111-122, (1978)

[6]

Lubin J.H., Gail M.H., Ershow A.G., Sample size and power for case‐control studies when exposures are continuous, Statistics in Medicine, 7, pp. 363-376, (1988)

[7]

McKeown-Eyssen G.E., Thomas D.C., Sample size determination in case control studies: the influence of the distribution of exposure, Journal of Chronic Diseases, 38, pp. 559-568, (1985)

[8]

Lui K.-J., (1989)

[9]

Becker S., Sample size determination in case control studies, Journal of Chronic Diseases, 40, pp. 1141-1143, (1987)

[10]

Wilson S.R., Gordon I., Calculating sample sizes in the presence of confounding variables, Applied Statistics, 35, pp. 207-213, (1986)

← 1 2 →