DETERMINATION OF PROSTAGLANDIN-F2-ALPHA, PROSTAGLANDIN-E2, PROSTAGLANDIN-D2 AND PROSTAGLANDIN-6-KETO-F1-ALPHA IN HUMAN CEREBROSPINAL-FLUID

Prostaglandin (PG)F2α, E2, D2 and 6-keto-F1α were determined in human cerebrospinal fluid by a mass spectrometric technique. The samples were obtained from 12 patients with suspected intracranial disease. A 64 fold variation in PG levels was observed. The major PG was 6-keto-F1α (0.12-15 ng/ml). PGF2α and PGE2 were present in lower concentrations PGD2 was below the level of detection (0.05 ng/ml) except in one patient with extremely high total levels of PGs. © 1979.