USE OF SHED SNAKE SKIN AS A MODEL MEMBRANE FOR INVITRO PERCUTANEOUS PENETRATION STUDIES - COMPARISON WITH HUMAN SKIN

被引：74

作者：

ITOH, T ^{[1
]}

XIA, J ^{[1
]}

MAGAVI, R ^{[1
]}

NISHIHATA, T ^{[1
]}

RYTTING, JH ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT PHARMACEUT CHEM,LAWRENCE,KS 66045

来源：

PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 10期

关键词：

Azone; Elaphe obsoleta; functional group contribution; shed snake skin; skin penetration; transdermal;

D O I：

10.1023/A:1015943200982

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The potential usefulness of shed snake skin as a model membrane for transdermal research was examined. There are similarities between shed snake skin and human stratum corneum in terms of structure, composition, lipid content, water permeability, etc. The permeability of various compounds and the contribution of several functional groups to the permeability were also found to be similar between shed snake skin and human skin. Moreover, the permeability of compounds through shed snake skin was increased by Azone, one of the most extensively studied transdermal penetration enhancers. Considering the similarities between shed snake skin and human skin, ease of storage and handling, and low cost, shed snake skin may offer a good model membrane for transdermal research. © 1990, Plenum Publishing Corporation. All rights reserved.

引用

页码：1042 / 1047

页数：6

共 39 条

[1] INFLUENCE OF 1-DODECYLHEXAHYDRO-2H-AZEPIN-2-ONE (AZONE) ON THE INVITRO PERMEATION OF VERAPAMIL HYDROCHLORIDE ACROSS RAT, HAIRLESS MOUSE, AND HUMAN CADAVER SKIN [J].