ENDOTHELIN STIMULATES BOTH CAMP FORMATION AND PHOSPHATIDYLINOSITOL HYDROLYSIS IN CULTURED EMBRYONIC BOVINE TRACHEAL CELLS

被引：50

作者：

ODA, K

FUJITANI, Y

WATAKABE, T

INUI, T

OKADA, T

URADE, Y

OKUDAASHITAKA, E

ITO, S

机构：

[1] CIBA GEIGY JAPAN LTD,INT RES LAB,10-66 MIYUKI CHO,TAKARAZUKA 665,JAPAN

[2] OSAKA BIOSCI INST,DEPT CELL BIOL,SUITA,OSAKA 565,JAPAN

来源：

FEBS LETTERS | 1992年 / 299卷 / 02期

关键词：

ENDOTHELIN; RECEPTOR; CAMP; PHOSPHATIDYLINOSITOL TURNOVER;

D O I：

10.1016/0014-5793(92)80244-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Embryonic bovine tracheal (EBTr) cells were found to possess receptors for endothelin (ET) of ET-1-selective (ET(A)) subtype with a K(d) for ET-1 of 114 pM and a B(max) of 12.9 fmol/10(5) cells. Stimulation of EBTr cells with 100 pM to 100 nM ET-1 increased the contents of both inositol phosphates and cAMP in a concentration-dependent manner, indicating that the receptors are coupled to both phosphatidylinositol hydrolysis and cAMP formation in EBTr cells.

引用

页码：187 / 191

页数：5

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