AMORPHISM AND PHYSICOCHEMICAL STABILITY OF SPRAY-DRIED FRUSEMIDE

被引:23
作者
MATSUDA, Y
OTSUKA, M
ONOE, M
TATSUMI, E
机构
[1] Department of Pharmaceutical Technology, Kobe Women's College of Pharmacy, Kobe, 658, 4–19‐1, Higashi‐Nada, Motoyama-Kitamachi
关键词
D O I
10.1111/j.2042-7158.1992.tb05483.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The physicochemical properties of amorphous forms of frusemide, prepared by spray-drying at 50 or 150-degrees-C, and their hygroscopic stability at temperatures of 25 and 40-degrees-C, and at 0 and 75% relative humidity were investigated. The glass transition temperature of the amorphous form A was 44.2-degrees-C as measured by differential scanning calorimetry, while that of the amorphous form B was 54.4-degrees-C. The activation energies for glass transition and crystallization processes were calculated from the differential scanning calorimetry thermograms of amorphous forms A and B. respectively. Stability determined by X-ray diffraction at 0% relative humidity, 25 and 40-degrees-C suggested that form B was more stable than form A. However, the stability of form A at 75% relative humidity and 25 and 40-degrees-C was similar to that of form B.
引用
收藏
页码:627 / 633
页数:7
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