SYNTHESIS OF METHYLENECYCLOBUTYL ADENINE AND CYCLOBUTENYL ADENINE, POTENT ANTIVIRAL CARBOCYCLIC ANALOGS OF OXETANOCIN-A

被引：9

作者：

MARUYAMA, T

HANAI, Y

SATO, Y

机构：

[1] Department of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho

来源：

NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 2-4期

关键词：

D O I：

10.1080/07328319208021745

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

9-Cyclobutyladenines bearing both methylene and hydroxymethyl groups, 3 and 4, were prepared by dehydration of carbocyclic oxetanocin A (1a). Introduction of a double bond into cyclobutane ring was achieved by allylic oxidation of N6-benzoyl-9-[3-methylenecyclobutyl]adenine (12), which after several steps, afforded 9-[3-(hydroxy-methyl)-2-cyclobutenyl)adenine (5).

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页码：855 / 864

页数：10

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