FINASTERIDE IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA - A URODYNAMIC EVALUATION

被引:42
作者
KIRBY, RS [1 ]
BRYAN, J [1 ]
EARDLEY, I [1 ]
CHRISTMAS, TJ [1 ]
LIU, S [1 ]
HOLMES, SAV [1 ]
VALE, JA [1 ]
SHANMUGANATHAN, K [1 ]
WEBB, JA [1 ]
机构
[1] ST BARTHOLOMEWS HOSP,DEPT RADIOL,LONDON EC1A 7BE,ENGLAND
来源
BRITISH JOURNAL OF UROLOGY | 1992年 / 70卷 / 01期
关键词
D O I
10.1111/j.1464-410X.1992.tb15666.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
A group of 69 men with bladder outflow obstruction due to benign prostatic hyperplasia (BPH) were treated in a double-blind, placebo-controlled study with finasteride (Proscar, MK-906), a 5-alpha reductase inhibitor, 5 mg or 10 mg/day or placebo for 3 months; subsequently, 20 patients received finasteride 5 mg/day for a further 9 months in an open extension study. In treated patients dihydrotestosterone declined by over 60%, remaining unchanged with placebo. Symptom scores fell significantly in all 3 groups. Mean maximum flow rates fell slightly in placebo-treated patients but improved by 1.5 ml/s in the 10 mg group and by 3.3 ml/s in the 5 mg group. After 1 year's treatment, the reduction in symptom score and increase in flow rate were well maintained; the mean prostate volume was reduced by 14% and prostatic specific antigen declined by 28%. It was concluded that finasteride shows some efficacy in the treatment of BPH, with minimal toxicity, but 12 months of therapy or longer may be necessary to achieve maximal eff ect.
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页码:65 / 72
页数:8
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