IMPAIRED GLUCOSE EFFECTIVENESS IN PATIENTS WITH POLYCYSTIC-OVARY-SYNDROME

被引：18

作者：

FALCONE, T ^{[1
]}

LITTLE, AB ^{[1
]}

MORRIS, D ^{[1
]}

机构：

[1] ROYAL VICTORIA HOSP,DEPT MED,687 PINE AVE W,MONTREAL H3A 1A1,QUEBEC,CANADA

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 07期

关键词：

GLUCOSE EFFECTIVENESS (SG); INSULIN SENSITIVITY (SI);

D O I：

10.1093/oxfordjournals.humrep.a137771

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Insulin resistance and glucose intolerance are common features of polycystic ovary syndrome (PCOS). We have investigated the effect of glucose on the fractional glucose disappearance in patients with PCOS and in age- and weight-matched control subjects. The minimal model method as applied to a frequently sampled intravenous glucose tolerance test was employed. The insulin sensitivity index (S(i)) and glucose effectiveness (SG) were calculated with the MINMOD program. Testosterone, androstenedione and free testosterone concentrations were significantly higher in PCOS subjects. Glucose-induced glucose clearance (SG) and insulin sensitivity were significantly lower in PCOS subjects than controls [SG: 2.7 +/- 0.3 versus 1.8 +/- 0.1 x 100/min; P < 0.01; S(i): 133.4 +/- 20.0 versus 65.6 +/- 6.4/min (nmol/ml)]. Six PCOS women had an SG value within the normal range (> 2.0 x 100/min) but had a similar S(i) to that found in PCOS women with abnormal SG. We suggest that independent alterations in both glucose- and insulin-mediated glucose uptake occur in patients with PCOS. The underlying disturbance in glucose effectiveness may be similar to that found in familial non-insulin dependent diabetes mellitus.

引用

页码：922 / 925

页数：4

共 13 条

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