ACUTE ALCOHOL ADMINISTRATION TO MICE INDUCES HEPATIC SINUSOIDAL ENDOTHELIAL-CELL DYSFUNCTION

被引：8

作者：

DEACIUC, IV ^{[1
]}

SPITZER, JJ ^{[1
]}

SHELLITO, JE ^{[1
]}

DSOUZA, NB ^{[1
]}

机构：

[1] LOUISIANA STATE UNIV,MED CTR,DEPT MED,NEW ORLEANS,LA 70112

来源：

INTERNATIONAL HEPATOLOGY COMMUNICATIONS | 1994年 / 2卷 / 02期

关键词：

PLASMA HYALURONAN; HYALURONAN UPTAKE; PERFUSED MOUSE LIVER; SINUSOIDAL ENDOTHELIAL CELL; ETHANOL; LIPOPOLYSACCHARIDE;

D O I：

10.1016/0928-4346(94)90016-7

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Ethanol administration to mice (4.4 g kg(-1) body wt., i.p.) induced a marked increase (125%) in plasma hyaluronan (HA) concentration associated with a significant decrease (46%) in HA uptake by the isolated, perfused liver. Similar changes were obtained after i.v. administration of Escherichia coli lipopolysaccaharide (1 mg kg(-1) body wt.), a strong activator of Kupffer cells. Since: (a) hepatic HA uptake is predominantly a function of the sinusoidal endothelial cells, reflecting their functional stale, and (b) liver is a major site of HA clearance from the blood, we conclude that alcohol alters sinusoidal endothelial cell functions, including HA endocytosis. Changes in Kupffer cell functional state may be a primary event underlying the effects of both ethanol and LPS on sinusoidal endothelial cells.

引用

页码：81 / 86

页数：6

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