DIURETIC AND VASODILATING ACTIONS OF TORASEMIDE

被引：17

作者：

UCHIDA, T

YAMANAGA, K

KIDO, H

OHTAKI, Y

WATANABE, M

机构：

来源：

CARDIOLOGY | 1994年 / 84卷

关键词：

TORASEMIDE; LOOP DIURETICS; DIURESIS; THROMBOXANE;

D O I：

10.1159/000176452

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The pharmacological profile of torasemide was examined in experimental animals. In normotensive Wistar rats, torasemide produced less kaliuresis at doses that were equipotent with furosemide in terms of natriuresis. Torasemide but not furosemide exerted a significant diuretic action in rats treated with deoxycorticosterone acetate. Both torasemide and furosemide increased plasma renin activity and aldosterone concentration, but only torasemide significantly inhibited aldosterone-receptor binding in rat kidney. Torasemide also inhibited vasoconstriction induced by thromboxane A(2) in isolated canine coronary artery.

引用

页码：14 / 17

页数：4

共 4 条

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