INHERITED FACTOR-H DEFICIENCY AND COLLAGEN TYPE-III GLOMERULOPATHY

被引：90

作者：

VOGT, BA

WYATT, RJ

BURKE, BA

SIMONTON, SC

KASHTAN, CE

机构：

[1] Department of Pediatrics, Rainbow Babies and Children's Hospital, Cleveland, Ohio

[2] Department of Pediatrics, University of Tennessee, Memphis, Tennessee

[3] Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota

[4] Department of Pathology, Minneapolis Children's Medical Center, Minneapolis, Minnesota

[5] Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota

来源：

PEDIATRIC NEPHROLOGY | 1995年 / 9卷 / 01期

关键词：

GLOMERULONEPHRITIS; FACTOR H; COMPLEMENT; BETA-1 H GLOBULIN; COLLAGEN TYPE III GLOMERULOPATHY;

D O I：

10.1007/BF00858956

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A non-immune complex-mediated glomerulonephritis associated with persistent hypocomplementemia occurred in a young boy. Measurement of complement components revealed complete factor H deficiency, inherited as an autosomal recessive trait. Evaluation of the renal lesion revealed extensive deposition of type III collagen suggestive of collagen type III glomerulopathy, a recently identified cause of chronic renal insufficiency in children and adults. This report represents the first association of inherited factor H deficiency with collagen type III glomerulopathy.

引用

页码：11 / 15

页数：5

共 19 条

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