ALUMINA AND SILICA-GEL AS VERSATILE SYNTHETIC TOOLS IN ORGANIC-SYNTHESIS - NEWLY DEVELOPED REACTIONS FOR ORGANIC-SYNTHESIS

During these two or three years, reactions which are carried out with the use of reagents adsorbed on alumina or silica gel have increasingly appeared and many compounds have become accessible in much simpler synthetic procedures. This new method for organic synthesis is based on the reasoning that high reactivities of reagents are reduced or adjusted by adsorption to produce high selectivity of reagents. Usually these reactions proceed selectively, cleanly, and give products in high yields. In some cases ordinary reaction of the reagent is completely inhibited by alumina or silica gel and a new reaction appears. These newly developed reactions are reviewed here, mainlY from the standpoint of organic synthesis. © 1979, The Society of Synthetic Organic Chemistry, Japan. All rights reserved.