STRUCTURE OF THE MURINE C-SIS PROTOONCOGENE (SIS, PDGFB) ENCODING THE B-CHAIN OF PLATELET-DERIVED GROWTH-FACTOR

被引：32

作者：

BONTHRON, DT

SULTAN, P

COLLINS, T

机构：

[1] BRIGHAM & WOMENS HOSP,DEPT PATHOL,DIV VASC RES,BOSTON,MA 02115

[2] HARVARD UNIV,CAMBRIDGE,MA 02138

[3] JOHN RADCLIFFE HOSP,INST MOLEC MED,DEPT PAEDIAT,OXFORD OX3 9DU,ENGLAND

来源：

GENOMICS | 1991年 / 10卷 / 01期

关键词：

D O I：

10.1016/0888-7543(91)90515-G

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The murine proto-oncogene c-sis (Sis, PDGFB), encoding the B chain of platelet-derived growth factor, has been cloned. Its structure, with seven exons spanning approximately 20 kb, closely resembles that of the human and feline homologs. The predicted amino acid sequence of murine PDGF-B has residues 89% identical to those of human PDGF-B. A noncoding region at the start of exon 7, which is deleted by alternative splicing during the generation of the viral v-sis oncogene, is highly conserved in human, mouse, and cat and may represent an important regulatory element. © 1991.

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页码：287 / 292

页数：6

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