SYNTHESIS OF A DIHYDROPYRANO[3,2-E]INDOLE AS A ROTATIONALLY RESTRICTED PHENOLIC ANALOG OF THE NEUROTRANSMITTER SEROTONIN

被引：13

作者：

MACOR, JE

NEWMAN, ME

机构：

[1] Department of Medicinal Chemistry Central Research Division, Pfizer, Inc, Groton

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(00)92702-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-(2-Dimethylaminoethyl)-8,9-dihydropyrano[3,2-e]indole (1) has been synthesized via a six step procedure involving a Claisen rearrangement of a 5-allyloxyindole-3-glyoxamide. This novel heterocycle (1) represents a rotationally restricted phenolic analog of the neurotransmitter serotonin [3-(2-aminoethyl)-5-hydroxyindole].

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页码：3345 / 3348

页数：4

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