EFFECTS OF BENZYLPIPERAZINE DERIVATIVES ON THE NEUROTOXICITY OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE IN RAT-BRAIN

被引：15

作者：

HASHIMOTO, K ^{[1
]}

MAEDA, H ^{[1
]}

GOROMARU, T ^{[1
]}

机构：

[1] FUKUYAMA UNIV,FAC PHARM & PHARMACEUT SCI,FUKUYAMA,JAPAN

来源：

BRAIN RESEARCH | 1992年 / 590卷 / 1-2期

关键词：

3,4-METHYLENEDIOXYMETHAMPHETAMINE; NEUROTOXICITY; BENZYLPIPERAZINE; SEROTONIN; PARA-NITROBENZYLPIPERAZINE; PARA-CHLOROBENZYLPIPERAZINE; 1-PIPERONYLPIPERAZINE;

D O I：

10.1016/0006-8993(92)91119-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA) in rat brain was attenuated significantly by coadministration of several benzylpiperazines (p-nitrobenzylpiperazine, p-chlorobenzylpiperazine and 1-piperonylpiperazine), which were weak inhibitors for [H-3]6-nitroquipazine binding to the 5-hydroxytryptamine (5-HT) transporter in rat brain. These results suggest that these benzylpiperazines may inhibit the MDMA-induced neurotoxicity by a novel neuropharmacological effect other than 5-HT uptake inhibition.

引用

页码：341 / 344

页数：4

共 17 条

[1] MDMA-INDUCED NEUROTOXICITY - PARAMETERS OF DEGENERATION AND RECOVERY OF BRAIN-SEROTONIN NEURONS [J].

BATTAGLIA, G ;

YEH, SY ;

DESOUZA, EB .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1988, 29 (02) :269-274

[2]

BATTAGLIA G, 1987, J PHARMACOL EXP THER, V242, P911

[3]

COMMINS DL, 1987, J PHARMACOL EXP THER, V241, P338

[4]

HAHSIMOTO K, 1992, IN PRESS RES COMMUN, V13

[5] REDUCTION OF [H-3] 6-NITROQUIPAZINE-LABELED 5-HYDROXYTRYPTAMINE UPTAKE SITES IN RAT-BRAIN BY 3,4-METHYLENEDIOXYMETHAMPHETAMINE [J].

HASHIMOTO, K ;

GOROMARU, T .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1990, 4 (06) :635-641

[6] HIGH-AFFINITY BINDING OF [H-3] 6-NITROQUIPAZINE TO CORTICAL MEMBRANESIN THE RAT - INHIBITION BY 5-HYDROXYTRYPTAMINE AND 5-HYDROXYTRYPTAMINE UPTAKE INHIBITORS [J].

HASHIMOTO, K ;

GOROMARU, T .

NEUROPHARMACOLOGY, 1991, 30 (02) :113-117

[7]

HASHIMOTO K, IN PRESS EUR J PHARM

[8] 5-HYDROXYTRYPTAMINE UPTAKE BLOCKERS ATTENUATE THE 5-HYDROXYTRYPTAMINE-RELEASING EFFECT OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE AND RELATED AGENTS [J].

HEKMATPANAH, CR ;

PEROUTKA, SJ .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 177 (1-2) :95-98

[9] NEUROCHEMISTRY AND NEUROTOXICITY OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE (MDMA, ECSTASY) [J].

MCKENNA, DJ ;

PEROUTKA, SJ .

JOURNAL OF NEUROCHEMISTRY, 1990, 54 (01) :14-22

[10]

OHEARN E, 1988, J NEUROSCI, V8, P2788

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