SEQUENTIAL BILATERAL BUNDLE-BRANCH BLOCK DURING DOFETILIDE, A NEW CLASS-III ANTIARRHYTHMIC AGENT, IN A PATIENT WITH ATRIAL-FIBRILLATION

被引：14

作者：

CRIJNS, HJGM

KINGMA, JH

GOSSELINK, ATM

DALRYMPLE, HW

DELANGEN, CDJ

LIE, K

机构：

[1] Departments of Cardiology, University Hospital Groningen

[2] Departments of Clinical Pharmacology, University Hospital Groningen

[3] Department of Cardiology., St. Antonius Hospital, Nieuwegein

[4] Pfizer Central Research. Sandwich, Kent

来源：

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY | 1993年 / 4卷 / 04期

关键词：

ABERRANT CONDUCTION; BUNDLE BRANCH REENTRY; WIDE COMPLEX TACHYCARDIA; ANTIARRHYTHMIC THERAPY; ACTION POTENTIAL PROLONGATION;

D O I：

10.1111/j.1540-8167.1993.tb01283.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: The mechanism of wide QRS complex tachycardias during dofetilide infusion was studied in a patient with atrial fibrillation. Methods and Results: Endocardial recordings from the intraventricular conduction system showed that dofetilide caused ''classic'' aberrant conduction (Ashman phenomenon, typical QRS morphology) at high prematurity ratios (preceding interval = 1.78 X coupling interval -290), thus mimicking ventricular ectopy. In addition, there was frequent sequential bilateral bundle branch block, caused by a significant difference in preceding bundle-to-bundle intervals (mean difference +/- 1 SD: 74 +/- 26 msec). Conclusion: The present findings may prove helpful in the clinical assessment of wide QRS complex rhythms after dofetilide and possibly other ''Pure'' Class III antiarrhythmics.

引用

页码：459 / 466

页数：8

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