KAINATE-INDUCED SEIZURE ACTIVITY STIMULATES THE POLYAMINE INTERCONVERSION PATHWAY IN RAT-BRAIN

被引：32

作者：

BAUDRY, M

NAJM, I

机构：

[1] Neuroscience Program, HNB 311, University of Southern California, Los Angeles

来源：

NEUROSCIENCE LETTERS | 1994年 / 171卷 / 1-2期

关键词：

POLYAMINE; SEIZURE; HIPPOCAMPUS; LIMBIC SYSTEM; SPERMINE ACETYLTRANSFERASE;

D O I：

10.1016/0304-3940(94)90627-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Systemic injection of kainic acid in adult rat is accompanied by a large increase in the accumulation of acetylated derivatives of spermidine and spermine in the hippocampus and piriform cortex of animals pretreated with the polyamine oxidase inhibitor, MDL 72527. Furthermore, the activity of the enzyme spermine/spermidine acetyltransferase is increased at 8 and 16 h after kainate injection in piriform cortex and hippocampus. These results indicate that the polyamine interconversion pathway is rapidly activated in limbic areas following kainate-induced seizure activity, and suggest that this pathway might participate in the resulting neuronal damage.

引用

页码：151 / 154

页数：4

共 27 条

[1]

AMES BN, 1993, P NATL ACAD SCI USA, V90, P7015

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