A NEW METHOD FOR THE PREPARATION OF TETRAZOLES FROM NITRILES USING TRIMETHYLSILYLAZIDE/TRIMETHYLALUMINUM

被引：113

作者：

HUFF, BE

STASZAK, MA

机构：

[1] Lilly Research Laboratories Chemical Process Research and Development Indianapolis

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(00)61437-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tetrazoles are prepared in good yields from alkyl and aryl nitriles by treatment with equimolar trimethylaluminum and trimethylsilylazide. Yields, substrate compatibility, and reaction temperature are comparable with the use of other metal azides such as Al(N-3)(3) and n.Bu(3)SnN(3). The reactions are run in toluene or with added THF at 80 degrees C.

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页码：8011 / 8014

页数：4

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