HEAVY-CHAIN DIRECTED B-CELL MATURATION - CONTINUOUS CLONAL SELECTION BEGINNING AT THE PRE-B-CELL STAGE

被引：84

作者：

SCHWARTZ, RS ^{[1
]}

STOLLAR, BD ^{[1
]}

机构：

[1] TUFTS UNIV, SCH MED, DEPT BIOCHEM, BOSTON, MA 02111 USA

来源：

IMMUNOLOGY TODAY | 1994年 / 15卷 / 01期

关键词：

D O I：

10.1016/0167-5699(94)90022-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A number of laboratories have demonstrated a biased representation of certain V-region segments in the primary B-cell repertoire. This may reflect clonal selection at the pre-B cell stage of differentiation. Here, Robert Schwartz and David Stollar suggest that pre-B cells undergo positive selection directed by the presence of surface heavy chain with low affinity to autoantigen. This mechanism would account for the anti-self property of the pre-immune B-cell repertoire.

引用

页码：27 / 32

页数：6

共 70 条

[1] THE NATURAL AUTOANTIBODIES SYSTEM - BETWEEN HYPOTHESES AND FACTS [J].

AVRAMEAS, S ;

TERNYNCK, T .

MOLECULAR IMMUNOLOGY, 1993, 30 (12) :1133-1142

[2] CONTENT AND ORGANIZATION OF THE HUMAN IG VH LOCUS - DEFINITION OF 3 NEW VH FAMILIES AND LINKAGE TO THE IG CH LOCUS [J].

BERMAN, JE ;

MELLIS, SJ ;

POLLOCK, R ;

SMITH, CL ;

SUH, H ;

HEINKE, B ;

KOWAL, C ;

SURTI, U ;

CHESS, L ;

CANTOR, CR ;

ALT, FW .

EMBO JOURNAL, 1988, 7 (03) :727-738

[3] THE SCID MOUSE MUTANT - DEFINITION, CHARACTERIZATION, AND POTENTIAL USES [J].

BOSMA, MJ ;

CARROLL, AM .

ANNUAL REVIEW OF IMMUNOLOGY, 1991, 9 :323-350

[4] ISOLATION OF MYELIN BASIC PROTEIN-REACTIVE T-CELL LINES FROM NORMAL HUMAN-BLOOD [J].

BURNS, J ;

ROSENZWEIG, A ;

ZWEIMAN, B ;

LISAK, RP .

CELLULAR IMMUNOLOGY, 1983, 81 (02) :435-440

[5]

CASALI P, 1989, ANNU REV IMMUNOL, V7, P513, DOI 10.1146/annurev.iy.07.040189.002501

[6]

CHEN PP, 1987, J IMMUNOL, V139, P1727

[7] STRUCTURAL REPERTOIRE OF THE HUMAN V(H) SEGMENTS [J].

CHOTHIA, C ;

LESK, AM ;

GHERARDI, E ;

TOMLINSON, IM ;

WALTER, G ;

MARKS, JD ;

LLEWELYN, MB ;

WINTER, G .

JOURNAL OF MOLECULAR BIOLOGY, 1992, 227 (03) :799-817

[8] THE B-CELL ANTIGEN RECEPTOR COMPLEX - ASSOCIATION OF IG-ALPHA AND IG-BETA WITH DISTINCT CYTOPLASMIC EFFECTORS [J].

CLARK, MR ;

CAMPBELL, KS ;

KAZLAUSKAS, A ;

JOHNSON, SA ;

HERTZ, M ;

POTTER, TA ;

PLEIMAN, C ;

CAMBIER, JC .

SCIENCE, 1992, 258 (5079) :123-126

[9] NATURAL AUTOANTIBODIES MIGHT PREVENT AUTOIMMUNE-DISEASE [J].

COHEN, IR ;

COOKE, A .

IMMUNOLOGY TODAY, 1986, 7 (12) :363-364

[10] CLONAL ANALYSIS OF THE ANTI-DNA REPERTOIRE OF MURINE LYMPHOCYTES-B [J].

CONGER, JD ;

PIKE, BL ;

NOSSAL, GJV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (09) :2931-2935

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