ANALYSIS OF SEVOFLURANE DEGRADATION PRODUCTS IN VAPOR-PHASE SAMPLES

被引：13

作者：

CUNNINGHAM, DD

WEBSTER, J

NELSON, D

WILLIAMSON, B

机构：

[1] Solutions Development, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064, D-971

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1995年 / 668卷 / 01期

关键词：

D O I：

10.1016/0378-4347(95)00069-U

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Sevoflurane degradation products were measured by GC-flame ionization detection in vapor phase samples using manual and automated injection methods. Sample handling techniques allowed the transfer and storage of samples for up to 72 h. Compound A, fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, was the major vapor phase degradation product formed in simulated clinical conditions. Recoveries of 4-32 ppm (v/v) compound A concentrations using the manual method were in the range of 88-117% (n = 12, mean = 102%, R.S.D. = 9%).

引用

页码：41 / 52

页数：12

共 16 条

[1]

BITOH H, 1991, ANESTHESIOLOGY, V75, P343

[2] PERFORMANCE OF ABSORBENTS - EFFECT OF MOISTURE [J].