CHANGE IN THE AGE-OF-ONSET IN PATIENTS WITH FAMILIAL AMYLOIDOTIC POLYNEUROPATHY TYPE-I

被引：21

作者：

TASHIMA, K ^{[1
]}

ANDO, Y ^{[1
]}

TANAKA, Y ^{[1
]}

UCHINO, M ^{[1
]}

ANDO, M ^{[1
]}

机构：

[1] KUMAMOTO UNIV,SCH MED,DEPT INTERNAL MED 1,KUMAMOTO 860,JAPAN

来源：

INTERNAL MEDICINE | 1995年 / 34卷 / 08期

关键词：

AMYLOIDOSIS; AGE OF ONSET; TRANSTHYRETIN;

D O I：

10.2169/internalmedicine.34.748

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To investigate the influence of environmental factor(s) on the pathogenesis of familial amyloidotic polyneuropathy (FAP) type I, the age of onset in 33 FAP patients in the Arao district of Kumamoto Prefecture in Japan and in 20 of their ancestors to the 3rd prior generation was carefully examined. The age of onset in FAP patients progressively became younger. This tendency was more apparent in female FAP patients than in male patients. Since the pathogenesis of amyloid formation in FAP as well as other amyloidosis diseases is not still elucidated, this phenomenon may be of interest.

引用

页码：748 / 750

页数：3

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