INDUCIBLE NITRIC-OXIDE SYNTHASE IN THE CENTRAL-NERVOUS-SYSTEM

被引：32

作者：

SPARROW, JR

机构：

[1] Department of Ophthalmology, Cornell University Medical College, New York, 10021, NY

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 1994年 / 5卷 / 04期

关键词：

INDUCIBLE NITRIC OXIDE SYNTHASE; INOS; NITRIC OXIDE; NO; BRAIN; RETINA; SPINAL CORD; GLIA; NEURONS;

D O I：

10.1007/BF02736723

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is an accumulation of evidence indicating that induction of the calcium-independent isoform of nitric oxide synthase (iNOS) in glial cells can contribute to nitric oxide-mediated neural-cell damage. Elucidation of iNOS inducing signals and mechanisms regulating its augmentation and suppression may have implications for our understanding of basic processes underlying some forms of central nervous system disease.

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页码：219 / 229

页数：11

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