SIMPLE METHOD FOR THE REDUCTIVE DEHALOGENATION OF 9 ALPHA-BROMO STEROIDS

被引：17

作者：

PARNES, H

PEASE, J

机构：

[1] The Institute of Organic Chemistry, Syntex Research, Palo Alto

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 01期

关键词：

D O I：

10.1021/jo01315a038

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 11.beta.-hydroxy group is an important structural feature which contributes to the high biological activity of corticosteroids. Other substituents at C-11 might lead to new, highly active compounds. A new and efficient method for the reductive dehalogenation of 9.alpha.-bromo steroids using n-Bu3SnH is described.

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页码：151 / 152

页数：2

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