A MARINE MOLLUSK PROVIDES THE 1ST EXAMPLE OF INVIVO STORAGE OF PROSTAGLANDINS - PROSTAGLANDIN-1,15-LACTONES

被引：24

作者：

CIMINO, G ^{[1
]}

CRISPINO, A ^{[1
]}

DIMARZO, V ^{[1
]}

SODANO, G ^{[1
]}

SPINELLA, A ^{[1
]}

VILLANI, G ^{[1
]}

机构：

[1] CNR,IST CHIM MOLEC INTERESSE BIOL,VIA TOIANO 6,I-80072 NAPLES,ITALY

来源：

EXPERIENTIA | 1991年 / 47卷 / 01期

关键词：

PROSTAGLANDINS; PROSTAGLANDIN-1,15-LACTONES; PROSTAGLANDIN BIOSYNTHESIS; MARINE EICOSANOIDS; OPISTHOBRANCH MOLLUSKS;

D O I：

10.1007/BF02041252

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Prostaglandin- (PG) 1,15-lactones and, in smaller amounts, free acids, were isolated from both the mantle and the dorso-lateral appendices of the opisthobranch mollusc Tethys fimbria. In vivo conversion of PGs into the corresponding lactones and accumulation of PGE2- and PGE3-1,15-lactones in the appendages were shown. The detachment of these appendages from the molested mollusc caused the in vivo conversion of PGE2- and PGE3-lactones back to PGE2 and PGE3 respectively, thus providing the first example of a mechanism by which prostaglandins can be stored and, when needed, released.

引用

页码：56 / 60

页数：5