CINATRINS, A NOVEL FAMILY OF PHOSPHOLIPASE-A2 INHIBITORS .1. TAXONOMY AND FERMENTATION OF THE PRODUCING CULTURE - ISOLATION AND STRUCTURES OF CINATRINS

被引：37

作者：

ITAZAKI, H

NAGASHIMA, K

KAWAMURA, Y

MATSUMOTO, K

NAKAI, H

TERUI, Y

机构：

[1] Shionogi Research Laboratories, Shionogi & Co., Ltd., Fukushima-ku

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 01期

关键词：

D O I：

10.7164/antibiotics.45.38

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cinatrins A, B, C1, C2 and C3, a family of phospholipase A2 inhibitors were isolated from the fermentation broth of Circinotrichum falcatisporum RF-641. They were found to be novel spiro-gamma-dilactones and gamma-lactones derived from 1,2,3,5-tetra or 1,2,3(or 1,2,4)-trihydroxypentadecane-1,2,3-tricarboxylic acids. Structures were elucidated by MS and NMR studies and chemical transformations. The structure of cinatrin C3 was confirmed by X-ray crystallographic analysis, and its absolute configuration was determined by comparison of the CD spectra with related compounds.

引用

页码：38 / 49

页数：12