POKKURI, A DROSOPHILA GENE ENCODING AN E-26-SPECIFIC (ETS) DOMAIN PROTEIN, PREVENTS OVERPRODUCTION OF THE R7 PHOTORECEPTOR

被引：67

作者：

TEI, H ^{[1
]}

NIHONMATSU, I ^{[1
]}

YOKOKURA, T ^{[1
]}

UEDA, R ^{[1
]}

SANO, Y ^{[1
]}

OKUDA, T ^{[1
]}

SATO, K ^{[1
]}

HIRATA, K ^{[1
]}

FUJITA, SC ^{[1
]}

YAMAMOTO, D ^{[1
]}

机构：

[1] MITSUBISHI KASEI INST LIFE SCI,MACHIDA,TOKYO 194,JAPAN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 15期

关键词：

NEURONAL FATE DETERMINATION; COMPOUND EYE; TRANSCRIPTION FACTOR;

D O I：

10.1073/pnas.89.15.6856

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Studies on sevenless and bride of sevenless genes have revealed that the R8 cell plays a key role in the fate of the R7 photoreceptor cell, presenting on its surface an inductive cue to which R7 responds. sev-independent induction of R7 cells has been reported in the seven-up mutation, which appears to transform R1 and R6 cells to R7 cells. We have induced recessive mutations in a gene pokkuri (pok; pokkuri is a Japanese word that means "dropping dead") that lead to overproduction of R7 cells with rather minor effects on outer photoreceptors and R8 cells. Pok protein may function as a transcription factor, as the predicted amino acid sequence contains a region similar to the consensus established for the E-26-specific (Ets) domain.

引用

页码：6856 / 6860

页数：5

共 15 条

[1] LIGAND-INDEPENDENT ACTIVATION OF THE SEVENLESS RECEPTOR TYROSINE KINASE CHANGES THE FATE OF CELLS IN THE DEVELOPING DROSOPHILA EYE [J].