MODIFICATION OF ERYTHROCYTE-MEMBRANE LIPID-COMPOSITION INDUCED BY A SINGLE INTRAVENOUS-INFUSION OF PHOSPHOLIPID-TRIACYLGLYCEROL EMULSIONS IN MAN

被引：8

作者：

DAHLAN, W ^{[1
]}

RICHELLE, M ^{[1
]}

KULAPONGSE, S ^{[1
]}

ROSSLE, C ^{[1
]}

DECKELBAUM, RJ ^{[1
]}

CARPENTIER, YA ^{[1
]}

机构：

[1] UNIV LIBRE BRUXELLES,ERASMUS TECHNOL CTR,L DELOYERS LAB EXPTL SURG,40 AVE J WYBRAN,B-1070 BRUSSELS,BELGIUM

来源：

CLINICAL NUTRITION | 1992年 / 11卷 / 05期

关键词：

D O I：

10.1016/0261-5614(92)90001-7

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The study aimed to investigate whether, during short term infusion of lipid emulsions in man, red blood cell (RBC) membrane lipid composition was altered and RBC-free cholesterol (FC) could serve as a source of FC accumulated in the plasma. 3 normal subjects were infused intravenously with either 10% Intralipid [10% IL; PL:triglyceride (TG) weight ratio of 0.12] at the rates of 0.1, 0.2 and 0.3 g TG.kg-1.h-1 (providing PL intakes of 12, 24, 36 mg.kg-1.h-1, respectively) or with 30% Intralipid (30% IL; PL:TG ratio of 0.04) at the rate of 0.3 g TG.kg-1.h-1 (providing 12 mg PL.kg-1.h-1). Infusion of 10% IL at a slow rate and 30% IL at a high rate caused no change in RBC and plasma FC content. However, 10% IL infusion at intermediate and high rates induced a significant decrease in RBC-FC: PL ratio. This change was still present at 18 h after the cessation of high rate infusion. RBC-FC: PL ratio and plasma PL measured during infusion were significantly correlated (r = -0.87, p<0.001). FC efflux from RBC appears to contribute to the rise in plasma FC. This study indicates that the excessive amount of PL present as liposomes in some intravenous lipid emulsions can alter erythrocyte membrane lipid composition.

引用

页码：255 / 261

页数：7

共 35 条

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