INHIBITION OF INTERFERON GAMMA PRODUCTION BY PERIPHERAL-BLOOD MONONUCLEAR LEUKOCYTES OF PATIENTS WITH SARCOIDOSIS - PATHOGENIC IMPLICATIONS

被引：10

作者：

BERTRAN, G

ARZT, E

RESNIK, E

MOSCA, C

NAHMOD, V

机构：

[1] Depto. de Sustancias Vasoactivas, Instituto de Investigaciones Medicas, Universidad de Buenos Aires, Buenos Aires

来源：

CHEST | 1992年 / 101卷 / 04期

关键词：

D O I：

10.1378/chest.101.4.996

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Interferon gamma (IFN-gamma) production by stimulated peripheral mononuclear leukocytes of 30 patients with sarcoidosis was studied. A significant inhibition (64 percent, 5 to 330 IU/ml vs normal individuals = 1,000 +/- 250 IU/ml) in the IFN-gamma-synthesis was found. The inhibition is due to a defect in the circulating monocytes and not in the peripheral T lymphocytes of these patients. This defect in the peripheral IFN-gamma-production could be involved in the pathogenesis of this disease.

引用

页码：996 / 999

页数：4

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