RESOLUTION OF RACEMIC MIXTURES OF HYOSCYAMINE AND COLCHICINE ON IMPREGNATED SILICA-GEL LAYERS

被引：17

作者：

BHUSHAN, R

ALI, I

机构：

[1] Departement of Chemistry, University of Roorkee, Roorkee

来源：

CHROMATOGRAPHIA | 1993年 / 35卷 / 9-12期

关键词：

THIN-LAYER CHROMATOGRAPHY; ENANTIOMER SEPARATION; (+/-)-HYOSCYAMINE; (+/-)-COLCHICINE; LAYER; L-ASPARTIC ACID IMPREGNATED;

D O I：

10.1007/BF02267937

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The enantiomeric resolution of (+/-)-hyoscyamine (atropine) and (+/-)-colchicine was achieved on silica gel impregnated with an optically active acid, L-aspartic acid (.03 %), as the chiral selector. The solvent system n-butanol chloroform acetic acid water (3:6:4:1, v/v), was found to resolve (+/-) mixtures.

引用

页码：679 / 680

页数：2

共 12 条

[1]

ANSON ML, 1954, ADV PROTEIN CHEM, V9

[2] RESOLUTION OF ENANTIOMERIC MIXTURES OF PHENYLTHIOHYDANTOIN AMINO-ACIDS ON (+)-TARTARIC ACID-IMPREGNATED SILICA-GEL PLATES [J].

BHUSHAN, R ;

ALI, I .

JOURNAL OF CHROMATOGRAPHY, 1987, 392 :460-463

[3] TLC RESOLUTION OF ENANTIOMERIC MIXTURES OF AMINO-ACIDS [J].

BHUSHAN, R ;

ALI, I .

CHROMATOGRAPHIA, 1987, 23 (02) :141-142

[4]

DAVIES SG, 1989, CHEM BRIT, V25, P259

[5]

Finar IL, 1975, ORGANIC CHEM VOLUME, V5, P35

[6]

MANSKE RHF, 1955, ALKALOIDS CHEM PHYSL, V5

[7]

MANSKE RHF, 1952, ALKALOIDS CHEM PHYSL, V2

[8]

SHERMA J, 1988, ANAL CHEM, V60, pR74

[9] PLANAR CHROMATOGRAPHY [J].

SHERMA, J .

ANALYTICAL CHEMISTRY, 1990, 62 (12) :R371-R381

[10]

SHERMA J, 1986, ANAL CHEM, V58, pR69

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