SELECTIVE LOSS OF PALLIDAL DOPAMINE-D(2) RECEPTOR DENSITY IN HEPATIC-ENCEPHALOPATHY

被引：82

作者：

MOUSSEAU, DD

PERNEY, P

LAYRARGUES, GP

BUTTERWORTH, RF

机构：

[1] UNIV MONTREAL, HOP ST LUC, CLIN RES CTR ANDRE VIALLET, NEUROSCI RES UNIT, MONTREAL H2X 3J4, PQ, CANADA

[2] UNIV MONTREAL, HOP ST LUC, CLIN RES CTR ANDRE VIALLET, LIVER UNIT, MONTREAL H2X 3J4, PQ, CANADA

来源：

NEUROSCIENCE LETTERS | 1993年 / 162卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

DOPAMINE RECEPTOR; HEPATIC ENCEPHALOPATHY; HEPATIC COMA; HUMAN POSTMORTEM BRAIN; H-3]SPIPERONE BINDING; CIRRHOSIS;

D O I：

10.1016/0304-3940(93)90593-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The binding parameters of [H-3]SCH 23390 and [H-3]spiperone (radioligands for dopamine D1 and D2 receptors, respectively) were investigated in autopsied frontal cortex, caudate nucleus and globus pallidus/putamen of cirrhotic patients who died in hepatic coma as well as in age- and sex-matched controls. Specific [H-3]SCH 23390 binding site densities were unchanged in all regions; in contrast, specific [H-3]spiperone binding site density was decreased (by 44%, P<0.001) in the globus pallidus/putamen of patients with HE. Decreased densities of pallidal D2 binding sites could relate to the motor dysfunctions commonly encountered in human HE.

引用

页码：192 / 196

页数：5

共 33 条

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