OVARIAN-STEROID RECEPTOR EXPRESSION IN ENDOMETRIOSIS AND IN 2 POTENTIAL PARENT EPITHELIA - ENDOMETRIUM AND PERITONEAL MESOTHELIUM

被引：86

作者：

PRENTICE, A

RANDALL, BJ

WEDDELL, A

MCGILL, A

HENRY, L

HORNE, CHW

THOMAS, EJ

机构：

[1] Departments of Obstetrics and Gynaecology, Newcastle upon Tyne

[2] University Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne

[3] Departments of Biochemistry, Newcastle General Hospital, Newcastle upon Tyne

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 09期

关键词：

ENDOMETRIOSIS; ENDOMETRIUM; PERITONEUM; STEROID RECEPTORS;

D O I：

10.1093/oxfordjournals.humrep.a137848

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Endometriosis is an oestrogen dependent condition and it is expected that the tissue of origin of endometriosis will express receptors for the ovarian steroids. Two epithelia, endometrium and peritoneal mesothelium, are the potential parent epithelium. Oestrogen and progesterone receptor expression has been studied immunohistochemically in (i) timed endometrial biopsies from 25 normal subjects and 27 patients with endometriosis, (ii) 25 endometriotic biopsies and (iii) 42 peritoneal biopsies. Endometrium but not peritoneal mesothelium expresses both oestrogen and progesterone receptors. No difference in the intensity of staining between endometria of normal subjects compared with the endometria of patients with endometriosis was noted. In paired endometrial and endometriotic biopsies, the intensity of staining for the oestrogen receptor in stromal cells and for the progesterone receptor in both glandular and stromal cells was less in the endometriotic biopsies. These data provide circumstantial evidence for an endometrial origin for endometriosis although quantitative differences exist in receptor expression between endometrium and endometriosis.

引用

页码：1318 / 1325

页数：8

共 42 条

[1]

Barile G., Sica G., Motemurro A., Iacobelli S., Corradini M., Levels of estrogen and progesterone receptor in human endometrium during the menstrual cycle, Eur. J. Obstet. Gynecol. Reprod. Biol, 9, (1979)

[2]

Bayard F., Damilano S., Robel P., Baulieu E.-E., Cytoplasmic and nuclear estradiol and progesterone receptors in human endometrium, J. Clin. Endocrinol., 46, (1978)

[3]

Bergqvist A., Steroid Receptors in Endometriosis, pp. 33-55, (1991)

[4]

Bergqvist A., Jeppsson S., Kullander S., Ljungberg O., Human uterine endometrium and endometriotic tissue transplanted into nude mice. Morphologic effects of various steroid hormones, Am., 121, (1985)

[5]

Binns B.A.O., Baneijee R., Endometriosis with Turner’s syndrome treated with cyclical oestrogen/progesterone. Case report, Br. J. Obstet. Gynaecol., 90, pp. 581-582, (1983)

[6]

Brenner R.M., West N.B., McClellan M.C., Estrogen and progestin receptors in the reproductive tract of male and female primates, Biol. Reprod, 42, (1990)

[7]

Dizerega G.S., Barber D.L., Hodgen G.D., Endometriosis: Role of ovarian steroids in initiation, maintenance, and suppression, Fenil. Steal, 33, (1980)

[8]

Doty D.W., Gmber J.S., Wdf G.C., Winslow R.C., XY Pure gonadal dysgenesis. Report of 2 unusual cases, Obstet. Gyneco, 55, pp. 61S-65S, (1980)

[9]

Garcia E., Bouchard P., De Brux B., Berdah J., Frydman R., Schaison G., Milgrom E., Perrot-Applanat M., Use of immunocytochemistry of progesterone and estrogen receptors for endometrial dating, J. Clin. Endocrinol Metab, 67, (1988)

[10]

Goodman H.H., Kredentser D., Deligidisch L., Postmenopausal endometriosis associated with hormonal replacement therapy. A case report, J. Reprod. Med., 34, pp. 231-233, (1989)

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