CAPSAICIN ACTIVATES NEUROGENIC NONADRENERGIC NONCHOLINERGIC RELAXATIONS OF THE ISOLATED RAT DUODENUM

被引：33

作者：

MAGGI, CA ^{[1
]}

SANTICIOLI, P ^{[1
]}

MANZINI, S ^{[1
]}

MELI, A ^{[1
]}

机构：

[1] A MENARINI PHARMACEUT, DIV SMOOTH MUSCLE, RES LABS, DEPT PHARMACOL, VIA SETTE SANTI 3, I-50131 FLORENCE, ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1986年 / 120卷 / 03期

关键词：

D O I：

10.1016/0014-2999(86)90480-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Capsaicin induces a transient relaxation of the isolated rat duodenum in the presence of atropine plus guanethidine. The relaxant effect of capsaicin was not observed in vitro in the duodenum of capsaicin-pretreated animals. Capsaicin-induced relaxation was antagonized by tetrodotoxin or cold storage (24 h at 4.degree. C). It is concluded that capsaicin produces a neurogenic relaxation of the rat duodenum by activating an intramural non-adrenergic non-cholinergic mechanism which inhibits intestinal motility.

引用

页码：367 / 370

页数：4

共 10 条

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