DOPAMINE-BETA-HYDROXYLASE RELEASE FOLLOWING ACUTE SELECTIVE SYMPATHETIC-NERVE STIMULATION OF HEART, SPLEEN AND MESENTERY

被引：7

作者：

ALGATE, DR ^{[1
]}

LEACH, GDH ^{[1
]}

机构：

[1] UNIV BRADFORD, SCH PHARMACOL, BRADFORD BD7 1DP, W YORKSHIRE, ENGLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1978年 / 30卷 / 03期

关键词：

D O I：

10.1111/j.2042-7158.1978.tb13189.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An increase in the concentration of dopamine-.beta.-hydroxylase (DBH) in the blood perfusates of the heart spleen and mesentery of pithed rats was detected following selective sympathetic nerve stimulation. The concentration of enzyme released by each organ correlated with the stimulation frequency. The results provided further corroborative evidence that the concentration of DBH in the plasma is related to the degree of sympathetic tone. If the sampling methods described were applied to non-spinalized animals, the concentrations of DBH in organ perfusates could be used as an index of sympathetic nervous tone and provide a useful preparation for the study of drugs effects on the sympathetic nervous system.

引用

页码：162 / 166

页数：5

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