PLASMA AMINO-ACIDS IN NIGERIAN NUTRITIONAL ATAXIC NEUROPATHY

被引：44

作者：

OSUNTOKUN, BO

DUROWOJU, JE

MCFARLANE, H

WILSON, J

机构：

[1] Department of Psychiatry and Neurology, University College Hospital, Ibadan

[2] Department of Chemical Pathology, University College Hospital, Ibadan

[3] M.R.C. Clinical Genetics Research Unit, Institute of Neurology, London W.C.1, Queen's Square

来源：

BMJ-BRITISH MEDICAL JOURNAL | 1968年 / 3卷 / 5619期

关键词：

D O I：

10.1136/bmj.3.5619.647

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Investigation of nine patients with tropical ataxic neuropathy showed an absence or diminution of sulphur-containing amino-acids—cysteine and methionine—and a variable concentration of most other essential amino-acids. The pattern was unlike that found in kwashiorkor. The levels of serum cholesterol and total protein were normal, and the serum vitamin B12 levels were normal or high. Plasma thiocyanate concentration was high. All the patients gave a history of a monotonous diet of cassava derivatives. Cassava contains a cyanogenetic glycoside (linamarin) from which cyanide is released on hydrolysis. The excessive cyanide detoxication may be responsible for the low concentration of the sulphur-containing amino-acids. © 1968, British Medical Journal Publishing Group. All rights reserved.

引用

页码：647 / +

页数：1