FLUORIDE-ION CATALYZED ALKYLATION OF PURINES, PYRIMIDINES, NUCLEOSIDES AND NUCLEOTIDES USING ALKYLHALIDES

被引：20

作者：

OGILVIE, KK ^{[1
]}

BEAUCAGE, SL ^{[1
]}

GILLEN, MF ^{[1
]}

ENTWISTLE, D ^{[1
]}

QUILLIAM, M ^{[1
]}

机构：

[1] MCMASTER UNIV,DEPT CHEM,HAMILTON L8S 4L8,ONTARIO,CANADA

来源：

NUCLEIC ACIDS RESEARCH | 1979年 / 6卷 / 04期

关键词：

D O I：

10.1093/nar/6.4.1695

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alkyl halides react napidly with purines and pynimidines in the presence of fluoride ion. Alkylation of thymidine. leads to novel dimeric. nucleaside derivatives bridged through N3. Alknylation of thymidine mono and dinucleotides leads to alkylation at the base (N3) as well as diester and triester formation at the phosphate. © 1979 Information Retrieval Limited.

引用

页码：1695 / 1708

页数：14

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