EFFECTS OF LOW-DOSE BAPN ON WOUND-HEALING

Rats with subcutaneously implanted polyvinylalcohol sponges and with inflicted skin incision wounds received a single injection of β-aminopropionitrile at four dosages ranging from 40 to 1 mg per 100 g body wt. At 6, 24, and 48 hr after the injection, the activity of lysyl oxidase, extractability of collagen into neutral salt, and bursting strength of the wound were tested. We found that even the lowest dose of BAPN tested significantly inhibited lysyl oxidase activity for 6 hr; with larger dosages the inhibition lasted longer, at 40 mg BAPN, at least 48 hr. The magnitude and duration of lysyl oxidase inhibition by BAPN was reflected in the extractability of collagen and bursting strength of the wound. The data suggest that minimal dose of BAPN would be clinically effective if either the metabolism of the drug is reduced (by monoaminoxidase inhibitors) or by sustained release of BAPN from delivery systems. © 1979.