CYTOGENETIC EFFECTS OF RADIOTHERAPY - FREQUENCY AND TYPES OF CHROMOSOME-ABERRATIONS

被引：15

作者：

BARRIOS, L

CABALLIN, MR

MIRO, R

FUSTER, C

GUEDEA, F

SUBIAS, A

EGOZCUE, J

机构：

[1] UNIV AUTONOMA BARCELONA,HOSP SANTA CREU & SANT PAU,DEPT BIOL ANIM VEGETAL & ECOL,E-08193 BARCELONA,SPAIN

[2] UNIV AUTONOMA BARCELONA,HOSP SANTA CREU & SANT PAU,SERV ONCOL,E-08193 BARCELONA,SPAIN

[3] UNIV AUTONOMA BARCELONA,HOSP SANTA CREU & SANT PAU,INST BIOL FONAMENTAL VICENT VILLAR PALASI,E-08193 BARCELONA,SPAIN

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1990年 / 19卷 / 02期

关键词：

Chromosome aberrations; Radiotherapy;

D O I：

10.1016/0360-3016(90)90546-V

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The frequency and types of chromosome aberrations induced by ionizing radiation in cancer patients were evaluated in 24 cases studied just before and immediately after radiotherapy. The incidence of aberrant metaphases prior to treatment was 9.913% and increased significantly after treatment to 32.8%. The frequency of chromosome aberrations before radiotherapy was, with the exception of the cases of breast cancer and seminoma, significantly higher than that in our laboratory controls. A comparison of chromosome abnormalities observed before and after treatment indicated that dicentric translocations, rings, and reciprocal translocations increased by a factor of 23, 13, and 11, respectively, after radiotherapy. Ionizing radiation produces more asymmetrical than symmetrical chromosome aberrations and more two-break than one-break anomalies. © 1990.

引用

页码：371 / 375

页数：5

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