SIGNIFICANCE OF HLA MATCHING IN RENAL-TRANSPLANTATION - PROSPECTIVE ONE-CENTER STUDY OF 485 TRANSPLANTS MATCHED OR MISMATCHED FOR HLA-A,B,C,D, AND DR ANTIGENS

Matching for HLA haplotypes as well as for HLA-A and B antigens improved graft survival in 112 living related first transplants. In cadaveric first transplants, matching for HLA-A and B antigens had a beneficial effect on the fate of 373 grafts, while matching for HLA-C antigens had no predictive value. One hundred seventeen cadaveric transplants and their recipients were prospectively typed for the HLA-DR antigens. Compatibility for HLA-DR was found to be prognostically beneficial irrespective of matching for HLA-A and B antigens, and with no difference between transfused and nontransfused patients. Matching both for HLA-A, B and D/DR was thus found to influence the outcome of renal transplantation. © 1979 by The Williams and Wilkins Co.