NEW CHEMICAL-SERIES ACTIVE AGAINST AFRICAN TRYPANOSOMES - BENZYLTRIPHENYLPHOSPHONIUM SALTS

Antitrypanosomal activity for benzyltriphenylphosphonium salts is reported for the first time. Testing was conducted using Trypanosoma rhodesiense infected mice. of 70 phosphorus-containing compounds tested, 21 wereactive.Sixteen of these active chemical species were benzyltriphenylphosphonium salts. Four were nonbenzyl triphenyl compounds. The remaining active drug was a benzyldiphenylphosphonium salt. © 1979, American Chemical Society. All rights reserved.