PSYCHOTOMIMETICS POTENTIATE LOCOMOTOR HYPERACTIVITY INDUCED BY DOPAMINERGIC DRUGS

被引：24

作者：

FINK, H

MORGENSTERN, R

OELSSNER, W

机构：

[1] Institute of Pharmacology and Toxicology, Humboldt University, 108 Berlin

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 11卷 / 05期

关键词：

Amphetamine; Apomorphine; Cyproheptadine; Locomotor activity; Open-field; Psychotomimetics Rat;

D O I：

10.1016/0091-3057(79)90028-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The spontaneous locomotor activity of rats was investigated in an open-field test. Apomorphine and d, 1-amphetamine caused a dose dependent increase of locomotor activity. LSD, mescaline, and DMT in low doses were ineffective, when given alone, but caused a strong potentiation of the hypermotility induced by apomorphine and d, 1-amphetamine. Cyproheptadine antagonized the potentiating effect of LSD without affecting the hypermotility induced by apomorphine, indicating a casal serotenergic involvement in the potentiation effect. © 1979.

引用

页码：479 / 482

页数：4

共 20 条

[1]

AGHAJANIAN GK, 1970, J PHARMACOL EXP THER, V171, P178

[2] EVIDENCE FOR INVOLVEMENT OF 5-HYDROXYTRYPTAMINE IN ACTIONS OF AMPHETAMINE [J].