THE ANTIFUNGAL ACTIVITY OF SOME ALIPHATIC AND AROMATIC-ACIDS

The present paper deals with the relationship between biological activities of some aliphatic and aromatic acids and their physico-chemical parameters expressing the influence of hydrophobic factors. The test strain in the biotest of growth inhibition was the fungus Fusarium moniliforme CCMF-180 and Penicillium expansum CCMF-576. Significant relationship between antifungal activities of un-ionized form of aliphatic acids and their capacity factors (log k'0) extrapolated to pure water, partition coefficients determined in 1-octanol-water system (log P(oct)) and the first order of molecular connectivity indices (1-chi) were calculated. The ionized form of aliphatic acids were antifungally active, too. For benzoic acids significant relationships between antifungal activities and capacity factors of anionic form (log k'(ia)) were calculated.