USE OF APROTININ IN KNEE REPLACEMENT SURGERY

被引：35

作者：

THORPE, CM

MURPHY, WG

LOGAN, M

机构：

[1] UNIV EDINBURGH,ROYAL INFIRM,DEPT MED,EDINBURGH,MIDLOTHIAN,SCOTLAND

[2] SE SCOTLAND BLOOD TRANSFUS SERV,EDINBURGH,MIDLOTHIAN,SCOTLAND

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1994年 / 73卷 / 03期

关键词：

SURGERY; ORTHOPEDIC; BLOOD; COAGULATION; POLYPEPTIDES; APROTININ;

D O I：

10.1093/bja/73.3.408

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

We have studied the effect of aprotinin on blood loss and subsequent blood transfusion in 17 patients undergoing knee replacement surgery. Patients receiving aprotinin (total dose 2 000 000 kallikrein inhibiting units) received fewer units of blood than control patients (P < 0.05), although there was no significant difference in blood loss between the two groups. The study was stopped when one patient in the aprotinin group needed an above-knee amputation because of ischaemia secondary to arteriovenous thrombosis replacement surgery. Although the after knee patient had peripheral vascular disease which could have accounted for the thrombosis, the role of aprotinin under tourniquet conditions is unclear.

引用

页码：408 / 410

页数：3

共 10 条

[1]

AOKI N, 1978, BLOOD, V52, P1

[2]

BIDSTRUP BP, 1989, J THORAC CARDIOV SUR, V97, P364

[3]

Bohrer H, 1990, J Cardiothorac Anesth, V4, P222, DOI 10.1016/0888-6296(90)90241-7

[4] AN ANALYSIS OF BLOOD-TRANSFUSION OF SURGICAL PATIENTS BY SEX - A QUEST FOR THE TRANSFUSION TRIGGER [J].

FRIEDMAN, BA ;

BURNS, TL ;

SCHORK, MA .

TRANSFUSION, 1980, 20 (02) :179-188

[5]

HAAS S, 1985, THROMB HAEMOSTASIS, V54, P99

[6] HIGH-DOSE APROTININ REDUCES BLOOD-LOSS IN PATIENTS UNDERGOING TOTAL HIP-REPLACEMENT SURGERY [J].

JANSSENS, M ;

JORIS, J ;

DAVID, JL ;

LEMAIRE, R ;

LAMY, M .

ANESTHESIOLOGY, 1994, 80 (01) :23-29

[7]

MURKIN JM, 1993, ANESTHESIOLOGY, V79, pA58

[8]

Royston D, 1992, J Cardiothorac Vasc Anesth, V6, P76, DOI 10.1016/1053-0770(91)90052-U

[9]

ROYSTON D, 1987, LANCET, V2, P1289

[10] APROTININ IN PERIPHERAL VASCULAR-SURGERY [J].

THOMPSON, JF ;

ROATH, OS ;

FRANCIS, JL ;

WEBSTER, JHH ;

CHANT, ADB .

LANCET, 1990, 335 (8694) :911-911

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