THE MAEDI-VISNA VIRUS TAT PROTEIN INDUCES MULTIORGAN LYMPHOID HYPERPLASIA IN TRANSGENIC MICE

被引:8
作者
VELLUTINI, C
PHILIPPON, V
GAMBARELLI, D
HORSCHOWSKI, N
NAVE, KA
NAVARRO, JM
AUPHAN, M
COURCOUL, MA
FILIPPI, P
机构
[1] INSERM,U372,VIROL LAB,F-13276 MARSEILLE 09,FRANCE
[2] CHU TIMONE,ANAT PATHOL LAB,MARSEILLE 05,FRANCE
[3] CHU TIMONE,HEMATOL LAB,MARSEILLE 05,FRANCE
[4] UNIV HEIDELBERG,ZMBH,D-69120 HEIDELBERG,GERMANY
关键词
D O I
10.1128/JVI.68.8.4955-4962.1994
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Sheep infected with maedi-visna virus experience immunological disorders leading to progressive chronic diseases involving the brain, lung, spleen, and lymph nodes. To study the biological activity of the viral transactivating Tat protein, we generated transgenic mice carrying the tat gene. Analysis of the transgenic mouse tissues for fat mRNA revealed that while low at the messenger level, the expression of the transgene correlated with dramatic follicular lymphoproliferative disorders involving the lung, spleen, lymph nodes, and skin. This finding suggests that the viral protein possesses a high pathological potency. Our findings show that the maedi-visna virus fat gene product contributes to the pathogenesis of multiorgan proliferative disorders associated with maedi-visna virus infection.
引用
收藏
页码:4955 / 4962
页数:8
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