SYNTHESIS AND ADRENOCORTICAL-INHIBITING ACTIVITY OF SUBSTITUTED 2,2-DIPHENETHYLAMINES

The synthesis and adrenal-inhibitory effects of a series of substituted 2,2-diphenethylamines are described. Most of the analogs appear to suppress adrenal steroidogenesis by inhibition of the 11-hydroxylation reaction. The introduction of methyl at C-2 of the aliphatic side chain of 2 appears to inhibit enzymatic reactions occurring early in the biosynthetic pathway, while the introduction of methyl at C-1 of 1 is followed by a highly selective inhibition of aldosterone biosynthesis. © 1969, American Chemical Society. All rights reserved.