ANALYSIS OF INFLAMMATORY CELLS AND COMPLEMENT-C3 IN BUPIVACAINE-INDUCED MYONECROSIS

被引：119

作者：

ORIMO, S ^{[1
]}

HIYAMUTA, E ^{[1
]}

ARAHATA, K ^{[1
]}

SUGITA, H ^{[1
]}

机构：

[1] KANTO TEISHIN HOSP,DEPT NEUROL,TOKYO,JAPAN

来源：

MUSCLE & NERVE | 1991年 / 14卷 / 06期

关键词：

INFLAMMATORY CELLS; MYONECROSIS; BUPIVACAINE; COMPLEMENT C3; IMMUNOHISTOCHEMISTRY;

D O I：

10.1002/mus.880140605

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Immunohistochemical analysis of the inflammatory cells and complement C3 in the rat skeletal muscle was performed chronologically in bupivacaine-induced myonecrosis. At 30 minutes after injection, polymorphonuclear leukocytes appeared and increased in number, with a peak value at 12 hours, while macrophages reached the highest level at 2 days. In contrast, T cells comprised only a small population. Two weeks after the injection, all types of the inflammatory cells returned to the normal level. Deposition of complement C3 was recognized at 60 minutes at the surface membrane of degenerating muscle fiber. Our observation suggests the importance of both polymorphonuclear leukocytes and complement C3 in the early stage, and macrophages in the later stage of bupivacaine-induced myonecrosis. In addition, our findings cast doubt on the pathological significance of T cells in this model.

引用

页码：515 / 520

页数：6

共 30 条

[1] MONOCLONAL-ANTIBODY ANALYSIS OF MONONUCLEAR-CELLS IN MYOPATHIES .5. IDENTIFICATION AND QUANTITATION OF T8+ CYTO-TOXIC AND T8+ SUPPRESSOR CELLS [J].