UK-1, A NOVEL CYTOTOXIC METABOLITE FROM STREPTOMYCES SP 517-02 .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

被引：131

作者：

UEKI, M

UENO, K

MIYADOH, S

ABE, K

SHIBATA, K

TANIGUCHI, M

OI, SM

机构：

[1] MEIJI SEIKA KAISHA LTD,PHARMACEUT TECHNOL LABS,ODAWARA,KANAGAWA 250,JAPAN

[2] SUNTORY LTD,INST BIOMED RES,MISHIMA,OSAKA 618,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 07期

关键词：

D O I：

10.7164/antibiotics.46.1089

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new benzoxazole, UK-1, was isolated from the mycelial cake of an actinomycete strain 517-02. Based on morphological, cultural and physiological characteristics, strain 517-02 was seemed to be a close relative of Streptomyces morookaense. UK-1 showed potent cytotoxic activity against B16, HeLa and P388 cells and did not show any antimicrobial activity.

引用

页码：1089 / 1094

页数：6

共 7 条

[1] CHEMICAL COMPOSITION OF CELL-WALL PREPARATIONS FROM STRAINS OF VARIOUS FORM-GENERA OF AEROBIC ACTINOMYCETES [J].