CD3-NEGATIVE LYMPHOPROLIFERATIVE DISEASE OF GRANULAR LYMPHOCYTES IN A GIRL WITH AN UNUSUAL PATTERN OF ANTI-EPSTEIN-BARR VIRUS-ANTIBODIES

被引：7

作者：

FUKUNAGA, Y ^{[1
]}

ASANO, T ^{[1
]}

TAKEHANA, J ^{[1
]}

AMBO, K ^{[1
]}

MATSUOKA, K ^{[1
]}

YAMAMOTO, M ^{[1
]}

机构：

[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT CELL BIOL,HOUSTON,TX 77030

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 1994年 / 153卷 / 12期

关键词：

GRANULAR LYMPHOCYTE; LYMPHOPROLIFERATIVE DISEASE OF GRANULAR LYMPHOCYTES; EPSTEIN-BARR VIRUS (EBV) GENOME; SEVERE CHRONIC ACTIVE EBV INFECTION SYNDROME;

D O I：

10.1007/BF01954741

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We describe an 11-year-old girl who initially had mild hepatosplenomegaly and then presented with abnormal expansion of CD3-negative 'granular lymphocytes in peripheral blood and Epstein-Barr virus (EBV) genome in the DNA obtained from the peripheral blood mononuclear cells (PBMNC). After approximately 3 years, she developed oedema, ascites, marked hepatosplenomegaly, and pancytopenia, and showed both a profile of anti-EBV antibodies of reactivated infection and a high titre of anti-cytomegalovirus antibody. Although she was treated with antibiotics, ganciclovir, and prednisolone, she died of hepatic failure. Conclusion Careful clinical observation, periodic examination of anti-EBV antibodies, and the analysis of EBV genome from PBMNC are needed in young patients with CD3-negative lymphoproliferative disease of granular lymphocytes.

引用

页码：894 / 897

页数：4

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