STRUCTURES OF A88696 C, D AND F - GASTRIC ATPASE INHIBITORS

被引：11

作者：

BONJOUKLIAN, R

MYNDERSE, JS

HUNT, AH

DEETER, JB

机构：

[1] Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(00)61494-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structures of A88696C (1), D (2) and F (3), isolated from Streptomyces sclerotialus, are described on the basis of spectroscopic analysis. 1 and 3 are spirotetronic acid-containing macrolides, and 2 is the beta-dicarbonyl tautomer with a spiroepoxide at the alpha-site of the lactone ring.

引用

页码：7857 / 7860

页数：4

共 8 条

[1]

BAYS DE, 1990, NAT PROD REP, V7, P365

[2]

BONJOUKLIAN R, 1993, TETRAHEDRON LETT, V34

[3] STUDIES ON THE MECHANISM OF ACTION OF A80915A, A SEMI-NAPHTHOQUINONE NATURAL PRODUCT, AS AN INHIBITOR OF GASTRIC (H+-K+)-ATPASE [J].