IDENTIFICATION OF ALPHA(2)-ADRENOCEPTORS IN RAT LYMPH-NODES AND SPLEEN - AN AUTORADIOGRAPHIC STUDY

被引：7

作者：

FERNANDEZLOPEZ, A

PAZOS, A

机构：

[1] UNIV CANTABRIA,DEPT PHYSIOL & PHARMACOL,PHARMACOL UNIT,E-39011 SANTANDER,SPAIN

[2] UNIV LEON,FAC BIOL,DEPT CELLULAR BIOL & ANAT,E-24071 LEON,SPAIN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 252卷 / 03期

关键词：

RECEPTOR AUTORADIOGRAPHY; ALPHA-2-ADRENOCEPTOR; LYMPH NODE; SPLEEN; H-3] BROMOXIDINE; IMMUNE SYSTEM;

D O I：

10.1016/0014-2999(94)90182-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The anatomical localization and pharmacological characteristics of alpha(2)-adrenoceptors were studied in rat lymphoid tissues by quantitative autoradiography with [H-3]bromoxidine as a ligand. In lymph nodes, a significant density of these receptors was found in the capsule, interfollicular cortex and medullary cords, while only very low densities were observed in the paracortex and germinal centres. In the spleen, these receptors appeared to be mainly distributed in the marginal zone of white pulp as well as in the red pulp. These results suggest a role for alpha(2)-adrenoceptors in the interaction between nervous and immune systems.

引用

页码：333 / 336

页数：4

共 12 条

[1] PARALLEL DEVELOPMENT OF NORADRENERGIC INNERVATION AND CELLULAR COMPARTMENTATION IN THE RAT SPLEEN [J].